Does Amiodarone Interact With Lithium?

Name: Does Amiodarone Interact With Lithium?
Creator: OmniRx Health

Table 1: Amiodarone Drug Interactions Concomitant Drug Class/Name Examples Clinical Comment Pharmacodynamic Interactions QT Prolonging Drugs class I and III antiarrhythmics, lithium, certain phenothiazines, tricyclic antidepressants, certain fluoroquinolone and macrolide antibiotics, azole antifungals, halogenated inhalation anesthetic agents Increased risk of Torsade de Pointes.

Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

Severity: Moderate

Severity basis: drug interactions section (keywords: increased risk). Combining Amiodarone (Class III antiarrhythmic) and Lithium (Mood stabilizer) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How This Interaction Works

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Amiodarone is a class iii antiarrhythmic and Lithium is a mood stabilizer; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

If You Take Both Medications

If you have been prescribed both Amiodarone and Lithium, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

From the FDA Label

Table 1: Amiodarone Drug Interactions Concomitant Drug Class/Name Examples Clinical Comment Pharmacodynamic Interactions QT Prolonging Drugs class I and III antiarrhythmics, lithium, certain phenothiazines, tricyclic antidepressants, certain fluoroquinolone and macrolide antibiotics, azole antifungals, halogenated inhalation anesthetic agents Increased risk of Torsade de Pointes.

Source: FDA structured product labeling (set_id 02f4a736-63ed-4ad4-a1f1-b21a71e928bd).

Amiodarone

Class III antiarrhythmic

Brands: Pacerone, Cordarone

View Amiodarone safety profile

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Check these against your full medication list in our free Interaction Checker

Frequently Asked Questions

Can you take Amiodarone and Lithium together?

Amiodarone and Lithium have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How serious is the Amiodarone and Lithium interaction?

It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: increased risk). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

What should I do if I'm taking both Amiodarone and Lithium?

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

Other Amiodarone Interactions

Other Lithium Interactions

Sources & References

Learn more about where our data comes from and how we write and review medical content.