Does Amiodarone Interact With Dabigatran?
The use of the P-gp inhibitors verapamil, amiodarone, quinidine, clarithromycin, and ticagrelor does not require a dosage adjustment of dabigatran etexilate.
Severity: Moderate
Severity basis: drug interactions section (keywords: dosage adjustment). Combining Amiodarone (Class III antiarrhythmic) and Dabigatran (Direct thrombin inhibitor) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Amiodarone is a class iii antiarrhythmic and Dabigatran is a direct thrombin inhibitor; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Amiodarone and Dabigatran, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
The use of the P-gp inhibitors verapamil, amiodarone, quinidine, clarithromycin, and ticagrelor does not require a dosage adjustment of dabigatran etexilate.
Source: FDA structured product labeling (set_id 13649035-a498-4e31-a7ea-8b18cedceca7).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Amiodarone and Dabigatran together?
Amiodarone and Dabigatran have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Amiodarone and Dabigatran interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: dosage adjustment). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Amiodarone and Dabigatran?
If you have been prescribed both Amiodarone and Dabigatran, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Amiodarone Interactions
- Amiodarone + Clarithromycin(major)
- Amiodarone + Levofloxacin(major)
- Amiodarone + Quetiapine(major)
- Amiodarone + Tizanidine(major)
- Amiodarone + Trazodone(major)
- Amiodarone + Azithromycin(moderate)
- Amiodarone + Carvedilol(moderate)
- Amiodarone + Fluconazole(moderate)
- Amiodarone + Lithium(moderate)
- Amiodarone + Lovastatin(moderate)
- Amiodarone + Phenytoin(moderate)
- Amiodarone + Tacrolimus(moderate)
- Amiodarone + Atenolol(minor)
- Amiodarone + Atorvastatin(minor)
- Amiodarone + Citalopram(minor)
- Amiodarone + Clonidine(minor)
- Amiodarone + Codeine(minor)
- Amiodarone + Cyclosporine(minor)
- Amiodarone + Digoxin(minor)
- Amiodarone + Diltiazem(minor)
- Amiodarone + Fluoxetine(minor)
- Amiodarone + Levothyroxine(minor)
- Amiodarone + Liothyronine(minor)
- Amiodarone + Prednisone(minor)
- Amiodarone + Propranolol(minor)
- Amiodarone + Simvastatin(minor)
- Amiodarone + Tramadol(minor)
- Amiodarone + Verapamil(minor)
- Amiodarone + Warfarin(minor)