Does Amiodarone Interact With Fluconazole?

Amiodarone : Concomitant administration of fluconazole with amiodarone may increase QT prolongation.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Amiodarone (Class III antiarrhythmic) and Fluconazole (Azole antifungal) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Amiodarone : Concomitant administration of fluconazole with amiodarone may increase QT prolongation.

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Amiodarone

Class III antiarrhythmic

Brands: Pacerone, Cordarone

View Amiodarone safety profile

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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