Does Apixaban Interact With Phenytoin?

7.2 Combined P-gp Strong CYP3A4 Inducers Avoid concomitant use of apixaban tablets with combined P-gp and strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin, St.

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Apixaban (Factor Xa inhibitor anticoagulant) and Phenytoin (Anticonvulsant) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

7.2 Combined P-gp Strong CYP3A4 Inducers Avoid concomitant use of apixaban tablets with combined P-gp and strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin, St.

Source: FDA structured product labeling (set_id 095a08ac-cf0e-497e-a682-ddef38d6b29c).

Apixaban

Factor Xa inhibitor anticoagulant

Brands: Eliquis

View Apixaban safety profile

Phenytoin

Anticonvulsant

Brands: Dilantin

View Phenytoin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.