Does Apixaban Interact With Clarithromycin?

Clarithromycin Although clarithromycin is a combined P-gp and strong CYP3A4 inhibitor, pharmacokinetic data suggest that no dose adjustment is necessary with concomitant administration with apixaban [see Clinical Pharmacology ( 12.3) ].

Severity: Minor

Severity basis: drug interactions section. Combining Apixaban (Factor Xa inhibitor anticoagulant) and Clarithromycin (Macrolide antibiotic) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Clarithromycin Although clarithromycin is a combined P-gp and strong CYP3A4 inhibitor, pharmacokinetic data suggest that no dose adjustment is necessary with concomitant administration with apixaban [see Clinical Pharmacology ( 12.3) ].

Source: FDA structured product labeling (set_id 095a08ac-cf0e-497e-a682-ddef38d6b29c).

Apixaban

Factor Xa inhibitor anticoagulant

Brands: Eliquis

View Apixaban safety profile

Clarithromycin

Macrolide antibiotic

Brands: Biaxin

View Clarithromycin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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