Does Aspirin Interact With Trazodone?
NSAIDs, Aspirin, or Other Drugs Affecting Coagulation or Bleeding Due to a possible association between serotonin modulating drugs and gastrointestinal bleeding, patients should be monitored for and cautioned about the potential risk of bleeding associated with the concomitant use of trazodone and NSAIDs, aspirin, or other drugs that affect coagulation or bleeding [s ee Warnings and Precautions ( 5.7 ) ].
Severity: Moderate
Severity basis: drug interactions section (keywords: monitor, caution). Combining Aspirin (Antiplatelet / NSAID) and Trazodone (Serotonin antagonist/reuptake inhibitor) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
NSAIDs, Aspirin, or Other Drugs Affecting Coagulation or Bleeding Due to a possible association between serotonin modulating drugs and gastrointestinal bleeding, patients should be monitored for and cautioned about the potential risk of bleeding associated with the concomitant use of trazodone and NSAIDs, aspirin, or other drugs that affect coagulation or bleeding [s ee Warnings and Precautions ( 5.7 ) ].
Source: FDA structured product labeling (set_id 007f38e0-653b-43e4-a1c1-b59997b2762a).
Trazodone
Serotonin antagonist/reuptake inhibitor
Brands: Desyrel, Oleptro
View Trazodone safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Aspirin Interactions
- Aspirin + Celecoxib(contraindicated)
- Aspirin + Indomethacin(contraindicated)
- Aspirin + Ketorolac(contraindicated)
- Aspirin + Meloxicam(contraindicated)
- Aspirin + Naproxen(contraindicated)
- Aspirin + Fluoxetine(major)
- Aspirin + Ibuprofen(major)
- Aspirin + Methotrexate(major)
- Aspirin + Montelukast(major)
- Aspirin + Alendronate(moderate)
- Aspirin + Citalopram(moderate)
- Aspirin + Desvenlafaxine(moderate)
- Aspirin + Edoxaban(moderate)
- Aspirin + Escitalopram(moderate)
- Aspirin + Methylprednisolone(moderate)
- Aspirin + Paroxetine(moderate)
- Aspirin + Rivaroxaban(moderate)
- Aspirin + Spironolactone(moderate)
- Aspirin + Valproic Acid(moderate)
- Aspirin + Apixaban(minor)
- Aspirin + Atenolol(minor)
- Aspirin + Atomoxetine(minor)
- Aspirin + Dexamethasone(minor)
- Aspirin + Diclofenac(minor)
- Aspirin + Duloxetine(minor)
- Aspirin + Enoxaparin(minor)
- Aspirin + Finasteride(minor)
- Aspirin + Furosemide(minor)
- Aspirin + Levothyroxine(minor)
- Aspirin + Nitroglycerin(minor)
- Aspirin + Oseltamivir(minor)
- Aspirin + Sertraline(minor)
- Aspirin + Sildenafil(minor)
- Aspirin + Tadalafil(minor)
- Aspirin + Venlafaxine(minor)
- Aspirin + Verapamil(minor)
- Aspirin + Warfarin(minor)
Other Trazodone Interactions
- Trazodone + Amiodarone(major)
- Trazodone + Clarithromycin(major)
- Trazodone + Itraconazole(major)
- Trazodone + Digoxin(moderate)
- Trazodone + Phenytoin(moderate)
- Trazodone + Warfarin(moderate)
- Trazodone + Buprenorphine Naloxone(minor)
- Trazodone + Buspirone(minor)
- Trazodone + Carbamazepine(minor)
- Trazodone + Clopidogrel(minor)
- Trazodone + Codeine(minor)
- Trazodone + Dabigatran(minor)
- Trazodone + Ketoconazole(minor)
- Trazodone + Lithium(minor)
- Trazodone + Morphine(minor)
- Trazodone + Oxycodone(minor)
- Trazodone + Rifampin(minor)
- Trazodone + Rivaroxaban(minor)
- Trazodone + Tramadol(minor)