Does Trazodone Interact With Warfarin?

Warfarin: Monitor for increased or decreased prothrombin time ( 7 ).

Severity: Moderate

Severity basis: drug interactions section (keywords: monitor). Combining Trazodone (Serotonin antagonist/reuptake inhibitor) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Warfarin: Monitor for increased or decreased prothrombin time ( 7 ).

Source: FDA structured product labeling (set_id 007f38e0-653b-43e4-a1c1-b59997b2762a).

Trazodone

Serotonin antagonist/reuptake inhibitor

Brands: Desyrel, Oleptro

View Trazodone safety profile

Warfarin

Vitamin K antagonist anticoagulant

Brands: Coumadin, Jantoven

View Warfarin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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