Does Rivaroxaban Interact With Trazodone?

Examples: warfarin, rivaroxaban, dabigatran, clopidogrel Strong CYP3A4 Inhibitors Clinical Impact: The concomitant use of trazodone and strong CYP3A4 inhibitors increased the exposure of trazodone compared to the use of trazodone alone .

Severity: Minor

Severity basis: drug interactions section. Combining Rivaroxaban (Factor Xa inhibitor anticoagulant) and Trazodone (Serotonin antagonist/reuptake inhibitor) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Examples: warfarin, rivaroxaban, dabigatran, clopidogrel Strong CYP3A4 Inhibitors Clinical Impact: The concomitant use of trazodone and strong CYP3A4 inhibitors increased the exposure of trazodone compared to the use of trazodone alone .

Source: FDA structured product labeling (set_id 007f38e0-653b-43e4-a1c1-b59997b2762a).

Rivaroxaban

Factor Xa inhibitor anticoagulant

Brands: Xarelto

View Rivaroxaban safety profile

Trazodone

Serotonin antagonist/reuptake inhibitor

Brands: Desyrel, Oleptro

View Trazodone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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