Does Carbamazepine Interact With Ibuprofen?

Concomitant use of carbamazepine with olanzapine, dantrolene, or ibuprofen may increase plasma carbamazepine levels.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Carbamazepine (Anticonvulsant) and Ibuprofen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Concomitant use of carbamazepine with olanzapine, dantrolene, or ibuprofen may increase plasma carbamazepine levels.

Source: FDA structured product labeling (set_id 047bc284-060a-4db9-bf37-75d10f95a0a6).

Carbamazepine

Anticonvulsant

Brands: Tegretol, Carbatrol

View Carbamazepine safety profile

Ibuprofen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Advil, Motrin

View Ibuprofen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.