Does Fluconazole Interact With Ibuprofen?

Similarly, the C max and AUC of the pharmacologically active isomer [S-(+)-ibuprofen] were increased by 15% and 82%, respectively, when fluconazole was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone.

Severity: Minor

Severity basis: drug interactions section. Combining Fluconazole (Azole antifungal) and Ibuprofen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Similarly, the C max and AUC of the pharmacologically active isomer [S-(+)-ibuprofen] were increased by 15% and 82%, respectively, when fluconazole was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone.

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Ibuprofen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Advil, Motrin

View Ibuprofen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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