Does Aspirin Interact With Ibuprofen?

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Aspirin is a antiplatelet / nsaid and Ibuprofen is a nonsteroidal anti-inflammatory drug (nsaid); together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Aspirin and Ibuprofen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Do not use if you are allergic to aspirin or any other pain reliever/fever reducer.

Source: FDA structured product labeling (set_id 0058175f-3474-40c3-a046-6cfaec86d84b).