Does Lansoprazole Interact With Rifampin?

Clinically Relevant Interactions Affecting Lansoprazole Delayed Release Capsules When CoAdministered with Other Drugs CYP2C19 OR CYP3A4 Inducers Clinical Impact: Decreased exposure of lansoprazole when used concomitantly with strong inducers [ see Clinical Pharmacology ( 12.3 )] Intervention : St John’s Wort, rifampin : Avoid concomitant use with Lansoprazole.

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Lansoprazole (Proton pump inhibitor) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

Clinically Relevant Interactions Affecting Lansoprazole Delayed Release Capsules When CoAdministered with Other Drugs CYP2C19 OR CYP3A4 Inducers Clinical Impact: Decreased exposure of lansoprazole when used concomitantly with strong inducers [ see Clinical Pharmacology ( 12.3 )] Intervention : St John’s Wort, rifampin : Avoid concomitant use with Lansoprazole.

Source: FDA structured product labeling (set_id 00a574e0-bd03-deea-9f85-b108f78982ba).

Lansoprazole

Proton pump inhibitor

Brands: Prevacid

View Lansoprazole safety profile

Rifampin

Rifamycin antibiotic (strong CYP3A4 inducer)

Brands: Rifadin

View Rifampin safety profile

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This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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