Does Clarithromycin Interact With Lansoprazole?

For information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with lansoprazole, refer to the CONTRAINDICATIONS section of their prescribing information.

Severity: Contraindicated

Severity basis: contraindications section (keywords: contraindications section). Combining Clarithromycin (Macrolide antibiotic) and Lansoprazole (Proton pump inhibitor) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

For information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with lansoprazole, refer to the CONTRAINDICATIONS section of their prescribing information.

Source: FDA structured product labeling (set_id 00a574e0-bd03-deea-9f85-b108f78982ba).

Clarithromycin

Macrolide antibiotic

Brands: Biaxin

View Clarithromycin safety profile

Lansoprazole

Proton pump inhibitor

Brands: Prevacid

View Lansoprazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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