Does Clarithromycin Interact With Rivaroxaban?
Although clarithromycin is a combined P-gp and strong CYP3A inhibitor, pharmacokinetic data suggests that no precautions are necessary with concomitant administration with XARELTO as the change in exposure is unlikely to affect the bleeding risk [see Clinical Pharmacology (12.3) ] .
Severity: Moderate
Severity basis: drug interactions section (keywords: caution). Combining Clarithromycin (Macrolide antibiotic) and Rivaroxaban (Factor Xa inhibitor anticoagulant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Although clarithromycin is a combined P-gp and strong CYP3A inhibitor, pharmacokinetic data suggests that no precautions are necessary with concomitant administration with XARELTO as the change in exposure is unlikely to affect the bleeding risk [see Clinical Pharmacology (12.3) ] .
Source: FDA structured product labeling (set_id 10db92f9-2300-4a80-836b-673e1ae91610).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Clarithromycin Interactions
- Clarithromycin + Colchicine(contraindicated)
- Clarithromycin + Lansoprazole(contraindicated)
- Clarithromycin + Lovastatin(contraindicated)
- Clarithromycin + Simvastatin(contraindicated)
- Clarithromycin + Amiodarone(major)
- Clarithromycin + Atorvastatin(major)
- Clarithromycin + Cyclosporine(major)
- Clarithromycin + Fluconazole(major)
- Clarithromycin + Fluticasone Salmeterol(major)
- Clarithromycin + Pioglitazone(major)
- Clarithromycin + Pravastatin(major)
- Clarithromycin + Quetiapine(major)
- Clarithromycin + Ticagrelor(major)
- Clarithromycin + Trazodone(major)
- Clarithromycin + Alprazolam(moderate)
- Clarithromycin + Amlodipine(moderate)
- Clarithromycin + Aripiprazole(moderate)
- Clarithromycin + Carbamazepine(moderate)
- Clarithromycin + Dabigatran(moderate)
- Clarithromycin + Digoxin(moderate)
- Clarithromycin + Diltiazem(moderate)
- Clarithromycin + Glimepiride(moderate)
- Clarithromycin + Itraconazole(moderate)
- Clarithromycin + Nifedipine(moderate)
- Clarithromycin + Phenytoin(moderate)
- Clarithromycin + Rifampin(moderate)
- Clarithromycin + Sildenafil(moderate)
- Clarithromycin + Tacrolimus(moderate)
- Clarithromycin + Tadalafil(moderate)
- Clarithromycin + Valproic Acid(moderate)
- Clarithromycin + Verapamil(moderate)
- Clarithromycin + Warfarin(moderate)
- Clarithromycin + Apixaban(minor)
- Clarithromycin + Eszopiclone(minor)
- Clarithromycin + Lorazepam(minor)
- Clarithromycin + Methylprednisolone(minor)
- Clarithromycin + Omeprazole(minor)
- Clarithromycin + Oxybutynin(minor)
- Clarithromycin + Temazepam(minor)
Other Rivaroxaban Interactions
- Rivaroxaban + Carbamazepine(major)
- Rivaroxaban + Itraconazole(major)
- Rivaroxaban + Ketoconazole(major)
- Rivaroxaban + Phenytoin(major)
- Rivaroxaban + Rifampin(major)
- Rivaroxaban + Aspirin(moderate)
- Rivaroxaban + Clopidogrel(moderate)
- Rivaroxaban + Enoxaparin(moderate)
- Rivaroxaban + Warfarin(moderate)
- Rivaroxaban + Trazodone(minor)