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    HomeMedication GuideDrug InteractionsHydroxychloroquine + Rifampin
    Minor interaction

    Does Hydroxychloroquine Interact With Rifampin?

    7.9 Rifampicin Lack of efficacy of hydroxychloroquine was reported when rifampicin was concomitantly administered.

    Severity: Minor

    Severity basis: drug interactions section. Combining Hydroxychloroquine (Antimalarial / DMARD) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a minor interaction.

    What to Do

    This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

    From the FDA Label

    7.9 Rifampicin Lack of efficacy of hydroxychloroquine was reported when rifampicin was concomitantly administered.

    Source: FDA structured product labeling (set_id 04139607-f7c0-4fe1-a210-ffa5af347d56).

    Hydroxychloroquine

    Antimalarial / DMARD

    Brands: Plaquenil

    View Hydroxychloroquine safety profile

    Rifampin

    Rifamycin antibiotic (strong CYP3A4 inducer)

    Brands: Rifadin

    View Rifampin safety profile

    Check these against your full medication list in our free Interaction Checker

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

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    Other Rifampin Interactions