Does Itraconazole Interact With Rifampin?
Drug Interactions with Other Drugs that Decrease Itraconazole Concentrations and May Reduce Efficacy of Itraconazole Antibacterials Isoniazid Rifampicin a Not recommended 2 weeks before and during itraconazole treatment.
Severity: Major
Severity basis: drug interactions section (keywords: not recommended). Combining Itraconazole (Azole antifungal (strong CYP3A4 inhibitor)) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
From the FDA Label
Drug Interactions with Other Drugs that Decrease Itraconazole Concentrations and May Reduce Efficacy of Itraconazole Antibacterials Isoniazid Rifampicin a Not recommended 2 weeks before and during itraconazole treatment.
Source: FDA structured product labeling (set_id 23126370-8d6a-4027-bd8f-860e2776ba3a).
Itraconazole
Azole antifungal (strong CYP3A4 inhibitor)
Brands: Sporanox, Tolsura
View Itraconazole safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Itraconazole Interactions
- Itraconazole + Colchicine(contraindicated)
- Itraconazole + Lovastatin(contraindicated)
- Itraconazole + Simvastatin(contraindicated)
- Itraconazole + Ticagrelor(contraindicated)
- Itraconazole + Apixaban(major)
- Itraconazole + Carbamazepine(major)
- Itraconazole + Fluticasone Salmeterol(major)
- Itraconazole + Phenytoin(major)
- Itraconazole + Rivaroxaban(major)
- Itraconazole + Sildenafil(major)
- Itraconazole + Tadalafil(major)
- Itraconazole + Tamsulosin(major)
- Itraconazole + Trazodone(major)
- Itraconazole + Alprazolam(moderate)
- Itraconazole + Aripiprazole(moderate)
- Itraconazole + Atorvastatin(moderate)
- Itraconazole + Budesonide(moderate)
- Itraconazole + Buprenorphine Naloxone(moderate)
- Itraconazole + Buspirone(moderate)
- Itraconazole + Ciprofloxacin(moderate)
- Itraconazole + Clarithromycin(moderate)
- Itraconazole + Cyclosporine(moderate)
- Itraconazole + Dabigatran(moderate)
- Itraconazole + Dexamethasone(moderate)
- Itraconazole + Diazepam(moderate)
- Itraconazole + Digoxin(moderate)
- Itraconazole + Diltiazem(moderate)
- Itraconazole + Fluticasone(moderate)
- Itraconazole + Methylprednisolone(moderate)
- Itraconazole + Mirtazapine(moderate)
- Itraconazole + Oxybutynin(moderate)
- Itraconazole + Oxycodone(moderate)
- Itraconazole + Quetiapine(moderate)
- Itraconazole + Risperidone(moderate)
- Itraconazole + Tacrolimus(moderate)
- Itraconazole + Venlafaxine(moderate)
- Itraconazole + Verapamil(moderate)
- Itraconazole + Warfarin(moderate)
- Itraconazole + Eszopiclone(minor)
- Itraconazole + Famotidine(minor)
- Itraconazole + Ketoconazole(minor)
- Itraconazole + Lansoprazole(minor)
- Itraconazole + Meloxicam(minor)
- Itraconazole + Montelukast(minor)
- Itraconazole + Pantoprazole(minor)
Other Rifampin Interactions
- Rifampin + Apixaban(major)
- Rifampin + Clopidogrel(major)
- Rifampin + Dabigatran(major)
- Rifampin + Doxycycline(major)
- Rifampin + Edoxaban(major)
- Rifampin + Fluconazole(major)
- Rifampin + Ketoconazole(major)
- Rifampin + Lansoprazole(major)
- Rifampin + Phenytoin(major)
- Rifampin + Rivaroxaban(major)
- Rifampin + Ticagrelor(major)
- Rifampin + Warfarin(major)
- Rifampin + Atorvastatin(moderate)
- Rifampin + Carvedilol(moderate)
- Rifampin + Clarithromycin(moderate)
- Rifampin + Cyclosporine(moderate)
- Rifampin + Eszopiclone(moderate)
- Rifampin + Gemfibrozil(moderate)
- Rifampin + Glimepiride(moderate)
- Rifampin + Glipizide(moderate)
- Rifampin + Hydrocodone Acetaminophen(moderate)
- Rifampin + Methylprednisolone(moderate)
- Rifampin + Mirtazapine(moderate)
- Rifampin + Oxycodone(moderate)
- Rifampin + Pioglitazone(moderate)
- Rifampin + Tacrolimus(moderate)
- Rifampin + Tramadol(moderate)
- Rifampin + Zolpidem(moderate)
- Rifampin + Aripiprazole(minor)
- Rifampin + Buprenorphine Naloxone(minor)
- Rifampin + Canagliflozin(minor)
- Rifampin + Carbamazepine(minor)
- Rifampin + Carbidopa Levodopa(minor)
- Rifampin + Celecoxib(minor)
- Rifampin + Codeine(minor)
- Rifampin + Dapagliflozin(minor)
- Rifampin + Dexamethasone(minor)
- Rifampin + Diazepam(minor)
- Rifampin + Digoxin(minor)
- Rifampin + Diltiazem(minor)
- Rifampin + Enalapril(minor)
- Rifampin + Glyburide(minor)
- Rifampin + Hydroxychloroquine(minor)
- Rifampin + Lamotrigine(minor)
- Rifampin + Levothyroxine(minor)
- Rifampin + Liothyronine(minor)
- Rifampin + Losartan(minor)
- Rifampin + Metoprolol(minor)
- Rifampin + Morphine(minor)
- Rifampin + Nifedipine(minor)
- Rifampin + Nortriptyline(minor)
- Rifampin + Olanzapine(minor)
- Rifampin + Ondansetron(minor)
- Rifampin + Prednisolone(minor)
- Rifampin + Propranolol(minor)
- Rifampin + Quetiapine(minor)
- Rifampin + Simvastatin(minor)
- Rifampin + Tadalafil(minor)
- Rifampin + Trazodone(minor)
- Rifampin + Valproic Acid(minor)
- Rifampin + Verapamil(minor)