Does Lamotrigine Interact With Rifampin?
Rifampin ↓ lamotrigine Decreased lamotrigine AUC approximately 40%.
Severity: Minor
Severity basis: drug interactions section. Combining Lamotrigine (Anticonvulsant / mood stabilizer) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Rifampin ↓ lamotrigine Decreased lamotrigine AUC approximately 40%.
Source: FDA structured product labeling (set_id 003663e5-c0c7-4fc1-a64d-313f2a5b10d2).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Lamotrigine Interactions
Other Rifampin Interactions
- Rifampin + Apixaban(major)
- Rifampin + Clopidogrel(major)
- Rifampin + Dabigatran(major)
- Rifampin + Doxycycline(major)
- Rifampin + Edoxaban(major)
- Rifampin + Fluconazole(major)
- Rifampin + Itraconazole(major)
- Rifampin + Ketoconazole(major)
- Rifampin + Lansoprazole(major)
- Rifampin + Phenytoin(major)
- Rifampin + Rivaroxaban(major)
- Rifampin + Ticagrelor(major)
- Rifampin + Warfarin(major)
- Rifampin + Atorvastatin(moderate)
- Rifampin + Carvedilol(moderate)
- Rifampin + Clarithromycin(moderate)
- Rifampin + Cyclosporine(moderate)
- Rifampin + Eszopiclone(moderate)
- Rifampin + Gemfibrozil(moderate)
- Rifampin + Glimepiride(moderate)
- Rifampin + Glipizide(moderate)
- Rifampin + Hydrocodone Acetaminophen(moderate)
- Rifampin + Methylprednisolone(moderate)
- Rifampin + Mirtazapine(moderate)
- Rifampin + Oxycodone(moderate)
- Rifampin + Pioglitazone(moderate)
- Rifampin + Tacrolimus(moderate)
- Rifampin + Tramadol(moderate)
- Rifampin + Zolpidem(moderate)
- Rifampin + Aripiprazole(minor)
- Rifampin + Buprenorphine Naloxone(minor)
- Rifampin + Canagliflozin(minor)
- Rifampin + Carbamazepine(minor)
- Rifampin + Carbidopa Levodopa(minor)
- Rifampin + Celecoxib(minor)
- Rifampin + Codeine(minor)
- Rifampin + Dapagliflozin(minor)
- Rifampin + Dexamethasone(minor)
- Rifampin + Diazepam(minor)
- Rifampin + Digoxin(minor)
- Rifampin + Diltiazem(minor)
- Rifampin + Enalapril(minor)
- Rifampin + Glyburide(minor)
- Rifampin + Hydroxychloroquine(minor)
- Rifampin + Levothyroxine(minor)
- Rifampin + Liothyronine(minor)
- Rifampin + Losartan(minor)
- Rifampin + Metoprolol(minor)
- Rifampin + Morphine(minor)
- Rifampin + Nifedipine(minor)
- Rifampin + Nortriptyline(minor)
- Rifampin + Olanzapine(minor)
- Rifampin + Ondansetron(minor)
- Rifampin + Prednisolone(minor)
- Rifampin + Propranolol(minor)
- Rifampin + Quetiapine(minor)
- Rifampin + Simvastatin(minor)
- Rifampin + Tadalafil(minor)
- Rifampin + Trazodone(minor)
- Rifampin + Valproic Acid(minor)
- Rifampin + Verapamil(minor)