Does Dabigatran Interact With Rifampin?
7 DRUG INTERACTIONS • P-gp inducers: Avoid coadministration with dabigatran etexilate capsules ( 5.5 ) • P-gp inhibitors in adult patients with CrCl 30 to 50 mL/min: Reduce dosage or avoid ( 7 ) • P-gp inhibitors in adult patients with CrCl <30 mL/min: Not recommended ( 7 ) 7.1 Reduction of Risk of Stroke and Systemic Embolism in Non-valvular Atrial Fibrillation in Adult Patients The concomitant use of dabigatran etexilate with P-gp inducers (e.g., rifampin) reduces exposure to dabigatran and…
Severity: Major
Severity basis: drug interactions section (keywords: avoid, not recommended). Combining Dabigatran (Direct thrombin inhibitor) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Dabigatran is a direct thrombin inhibitor and Rifampin is a rifamycin antibiotic (strong cyp3a4 inducer); together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Dabigatran and Rifampin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
7 DRUG INTERACTIONS • P-gp inducers: Avoid coadministration with dabigatran etexilate capsules ( 5.5 ) • P-gp inhibitors in adult patients with CrCl 30 to 50 mL/min: Reduce dosage or avoid ( 7 ) • P-gp inhibitors in adult patients with CrCl <30 mL/min: Not recommended ( 7 ) 7.1 Reduction of Risk of Stroke and Systemic Embolism in Non-valvular Atrial Fibrillation in Adult Patients The concomitant use of dabigatran etexilate with P-gp inducers (e.g., rifampin) reduces exposure to dabigatran and…
Source: FDA structured product labeling (set_id 13649035-a498-4e31-a7ea-8b18cedceca7).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Dabigatran and Rifampin together?
Dabigatran and Rifampin have a documented major interaction. The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How serious is the Dabigatran and Rifampin interaction?
It is classified as a major interaction, based on the FDA label's drug interactions section (keywords: avoid, not recommended). A major interaction can cause serious harm and often calls for a change in therapy or close monitoring.
What should I do if I'm taking both Dabigatran and Rifampin?
If you have been prescribed both Dabigatran and Rifampin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Dabigatran Interactions
Other Rifampin Interactions
- Rifampin + Apixaban(major)
- Rifampin + Clopidogrel(major)
- Rifampin + Doxycycline(major)
- Rifampin + Edoxaban(major)
- Rifampin + Fluconazole(major)
- Rifampin + Itraconazole(major)
- Rifampin + Ketoconazole(major)
- Rifampin + Lansoprazole(major)
- Rifampin + Phenytoin(major)
- Rifampin + Rivaroxaban(major)
- Rifampin + Ticagrelor(major)
- Rifampin + Warfarin(major)
- Rifampin + Atorvastatin(moderate)
- Rifampin + Carvedilol(moderate)
- Rifampin + Clarithromycin(moderate)
- Rifampin + Cyclosporine(moderate)
- Rifampin + Eszopiclone(moderate)
- Rifampin + Gemfibrozil(moderate)
- Rifampin + Glimepiride(moderate)
- Rifampin + Glipizide(moderate)
- Rifampin + Hydrocodone Acetaminophen(moderate)
- Rifampin + Methylprednisolone(moderate)
- Rifampin + Mirtazapine(moderate)
- Rifampin + Oxycodone(moderate)
- Rifampin + Pioglitazone(moderate)
- Rifampin + Tacrolimus(moderate)
- Rifampin + Tramadol(moderate)
- Rifampin + Zolpidem(moderate)
- Rifampin + Aripiprazole(minor)
- Rifampin + Buprenorphine Naloxone(minor)
- Rifampin + Canagliflozin(minor)
- Rifampin + Carbamazepine(minor)
- Rifampin + Carbidopa Levodopa(minor)
- Rifampin + Celecoxib(minor)
- Rifampin + Codeine(minor)
- Rifampin + Dapagliflozin(minor)
- Rifampin + Dexamethasone(minor)
- Rifampin + Diazepam(minor)
- Rifampin + Digoxin(minor)
- Rifampin + Diltiazem(minor)
- Rifampin + Enalapril(minor)
- Rifampin + Glyburide(minor)
- Rifampin + Hydroxychloroquine(minor)
- Rifampin + Lamotrigine(minor)
- Rifampin + Levothyroxine(minor)
- Rifampin + Liothyronine(minor)
- Rifampin + Losartan(minor)
- Rifampin + Metoprolol(minor)
- Rifampin + Morphine(minor)
- Rifampin + Nifedipine(minor)
- Rifampin + Nortriptyline(minor)
- Rifampin + Olanzapine(minor)
- Rifampin + Ondansetron(minor)
- Rifampin + Prednisolone(minor)
- Rifampin + Propranolol(minor)
- Rifampin + Quetiapine(minor)
- Rifampin + Simvastatin(minor)
- Rifampin + Tadalafil(minor)
- Rifampin + Trazodone(minor)
- Rifampin + Valproic Acid(minor)
- Rifampin + Verapamil(minor)