Does Rifampin Interact With Verapamil?

Name: Does Rifampin Interact With Verapamil?
Creator: OmniRx Health

Clinically significant interactions have been reported with inhibitors of CYP3A4 (e.g., erythromycin, ritonavir) causing elevation of plasma levels of verapamil while inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.

Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

Severity: Minor

Severity basis: drug interactions section. Combining Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) and Verapamil (Calcium channel blocker) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

How This Interaction Works

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Rifampin is a rifamycin antibiotic (strong cyp3a4 inducer) and Verapamil is a calcium channel blocker; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.

If You Take Both Medications

If you have been prescribed both Rifampin and Verapamil, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

From the FDA Label

Clinically significant interactions have been reported with inhibitors of CYP3A4 (e.g., erythromycin, ritonavir) causing elevation of plasma levels of verapamil while inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.

Source: FDA structured product labeling (set_id 006cf920-04ae-0b53-cb91-85481972abc2).

Rifampin

Rifamycin antibiotic (strong CYP3A4 inducer)

Brands: Rifadin

View Rifampin safety profile

Verapamil

Calcium channel blocker

Brands: Calan, Verelan

View Verapamil safety profile

Check these against your full medication list in our free Interaction Checker

Frequently Asked Questions

Can you take Rifampin and Verapamil together?

Rifampin and Verapamil have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

How serious is the Rifampin and Verapamil interaction?

It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.

What should I do if I'm taking both Rifampin and Verapamil?

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

Other Rifampin Interactions

Other Verapamil Interactions

Sources & References

Learn more about where our data comes from and how we write and review medical content.