Does Fluoxetine Interact With Tramadol?

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluoxetine is a ssri antidepressant and Tramadol is a opioid analgesic; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Fluoxetine and Tramadol, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

Suicidal thoughts and Behaviors in Children, Adolescents, and Young Adults: Monitor for clinical worsening and suicidal thinking and behavior ( 5.1 ) Serotonin Syndrome: Serotonin syndrome has been reported with SSRIs and SNRIs, including fluoxetine , both when taken alone, but especially when co-administered with other serotonergic agents (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St.

Source: FDA structured product labeling (set_id 02283de9-6087-45f7-a9ce-3b082ce860de).