Does Tramadol Interact With Warfarin?

Warfarin Clinical Impact: Post-marketing surveillance of tramadol has revealed rare reports of alteration of warfarin effect, including elevation of prothrombin times.

Severity: Minor

Severity basis: drug interactions section. Combining Tramadol (Opioid analgesic) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Warfarin Clinical Impact: Post-marketing surveillance of tramadol has revealed rare reports of alteration of warfarin effect, including elevation of prothrombin times.

Source: FDA structured product labeling (set_id 004de5a4-80f8-4040-a6ea-be5e99352a36).

Tramadol

Opioid analgesic

Brands: Ultram, ConZip

View Tramadol safety profile

Warfarin

Vitamin K antagonist anticoagulant

Brands: Coumadin, Jantoven

View Warfarin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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