Does Lithium Interact With Verapamil?

Lithium: Increased sensitivity to the effects of lithium (neurotoxicity) has been reported during concomitant verapamil-lithium therapy; lithium levels have been observed sometimes to increase, sometimes to decrease, and sometimes to be unchanged.

Severity: Minor

Severity basis: drug interactions section. Combining Lithium (Mood stabilizer) and Verapamil (Calcium channel blocker) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Lithium: Increased sensitivity to the effects of lithium (neurotoxicity) has been reported during concomitant verapamil-lithium therapy; lithium levels have been observed sometimes to increase, sometimes to decrease, and sometimes to be unchanged.

Source: FDA structured product labeling (set_id 006cf920-04ae-0b53-cb91-85481972abc2).

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Verapamil

Calcium channel blocker

Brands: Calan, Verelan

View Verapamil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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