Does Clarithromycin Interact With Itraconazole?

Antifungals: Itraconazole Use With Caution Itraconazole: Both clarithromycin and itraconazole are substrates and inhibitors of CYP3A, potentially leading to a bi-directional drug interaction when administered concomitantly (see also Itraconazole under “Drugs That Affect Clarithromycin Tablets” in the table below).

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Clarithromycin (Macrolide antibiotic) and Itraconazole (Azole antifungal (strong CYP3A4 inhibitor)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Antifungals: Itraconazole Use With Caution Itraconazole: Both clarithromycin and itraconazole are substrates and inhibitors of CYP3A, potentially leading to a bi-directional drug interaction when administered concomitantly (see also Itraconazole under “Drugs That Affect Clarithromycin Tablets” in the table below).

Source: FDA structured product labeling (set_id 0be243c6-de02-45dd-8210-cab1bbc8dfa7).

Clarithromycin

Macrolide antibiotic

Brands: Biaxin

View Clarithromycin safety profile

Itraconazole

Azole antifungal (strong CYP3A4 inhibitor)

Brands: Sporanox, Tolsura

View Itraconazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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