Does Lithium Interact With Naproxen?

Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance .

Severity: Minor

Severity basis: drug interactions section. Combining Lithium (Mood stabilizer) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance .

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.