Does Lithium Interact With Naproxen?
Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance .
Severity: Minor
Severity basis: drug interactions section. Combining Lithium (Mood stabilizer) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Lithium is a mood stabilizer and Naproxen is a nonsteroidal anti-inflammatory drug (nsaid); together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Lithium and Naproxen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance .
Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).
Naproxen
Nonsteroidal anti-inflammatory drug (NSAID)
Brands: Aleve, Naprosyn
View Naproxen safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Lithium and Naproxen together?
Lithium and Naproxen have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How serious is the Lithium and Naproxen interaction?
It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.
What should I do if I'm taking both Lithium and Naproxen?
If you have been prescribed both Lithium and Naproxen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Lithium Interactions
- Lithium + Olanzapine(contraindicated)
- Lithium + Amiodarone(moderate)
- Lithium + Aripiprazole(moderate)
- Lithium + Benazepril(moderate)
- Lithium + Canagliflozin(moderate)
- Lithium + Carbamazepine(moderate)
- Lithium + Dapagliflozin(moderate)
- Lithium + Empagliflozin(moderate)
- Lithium + Fluoxetine(moderate)
- Lithium + Hydrochlorothiazide(moderate)
- Lithium + Insulin Aspart(moderate)
- Lithium + Insulin Glargine(moderate)
- Lithium + Lisinopril(moderate)
- Lithium + Metronidazole(moderate)
- Lithium + Phenytoin(moderate)
- Lithium + Ramipril(moderate)
- Lithium + Spironolactone(moderate)
- Lithium + Topiramate(moderate)
- Lithium + Valsartan(moderate)
- Lithium + Amphetamine Dextroamphetamine(minor)
- Lithium + Buspirone(minor)
- Lithium + Celecoxib(minor)
- Lithium + Citalopram(minor)
- Lithium + Desvenlafaxine(minor)
- Lithium + Duloxetine(minor)
- Lithium + Enalapril(minor)
- Lithium + Escitalopram(minor)
- Lithium + Furosemide(minor)
- Lithium + Indomethacin(minor)
- Lithium + Irbesartan(minor)
- Lithium + Lisdexamfetamine(minor)
- Lithium + Losartan(minor)
- Lithium + Meloxicam(minor)
- Lithium + Mirtazapine(minor)
- Lithium + Nortriptyline(minor)
- Lithium + Olmesartan(minor)
- Lithium + Ondansetron(minor)
- Lithium + Paroxetine(minor)
- Lithium + Quetiapine(minor)
- Lithium + Risperidone(minor)
- Lithium + Sertraline(minor)
- Lithium + Telmisartan(minor)
- Lithium + Tramadol(minor)
- Lithium + Trazodone(minor)
- Lithium + Valproic Acid(minor)
- Lithium + Venlafaxine(minor)
- Lithium + Verapamil(minor)
Other Naproxen Interactions
- Naproxen + Aspirin(contraindicated)
- Naproxen + Diclofenac(major)
- Naproxen + Indomethacin(major)
- Naproxen + Cyclosporine(moderate)
- Naproxen + Methotrexate(moderate)
- Naproxen + Warfarin(moderate)
- Naproxen + Celecoxib(minor)
- Naproxen + Digoxin(minor)
- Naproxen + Fluconazole(minor)
- Naproxen + Furosemide(minor)
- Naproxen + Gabapentin(minor)
- Naproxen + Ibuprofen(minor)
- Naproxen + Meloxicam(minor)
- Naproxen + Propranolol(minor)
- Naproxen + Sucralfate(minor)