Does Cyclosporine Interact With Naproxen?

Cyclosporine Clinical Impact: Concomitant use of naproxen tablets or naproxen sodium tablets and cyclosporine may increase cyclosporine’s nephrotoxicity.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Cyclosporine Clinical Impact: Concomitant use of naproxen tablets or naproxen sodium tablets and cyclosporine may increase cyclosporine’s nephrotoxicity.

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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