Does Diclofenac Interact With Naproxen?

NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Diclofenac (Nonsteroidal anti-inflammatory drug (NSAID)) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).

Diclofenac

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Voltaren, Cambia

View Diclofenac safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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