Does Aspirin Interact With Naproxen?

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Aspirin is a antiplatelet / nsaid and Naproxen is a nonsteroidal anti-inflammatory drug (nsaid); together they are documented as a contraindicated interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Aspirin and Naproxen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

4 CONTRAINDICATIONS Naproxen tablets and naproxen sodium tablets are contraindicated in the following patients: • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to naproxen or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).