Does Aspirin Interact With Naproxen?

4 CONTRAINDICATIONS Naproxen tablets and naproxen sodium tablets are contraindicated in the following patients: • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to naproxen or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.

Severity: Contraindicated

Severity basis: contraindications section (keywords: contraindicated). Combining Aspirin (Antiplatelet / NSAID) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

4 CONTRAINDICATIONS Naproxen tablets and naproxen sodium tablets are contraindicated in the following patients: • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to naproxen or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).

Aspirin

Antiplatelet / NSAID

Brands: Bayer, Ecotrin, Bufferin

View Aspirin safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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