Does Fluconazole Interact With Naproxen?

Name: Does Fluconazole Interact With Naproxen?
Creator: OmniRx Health

Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).

Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

Severity: Minor

Severity basis: drug interactions section. Combining Fluconazole (Azole antifungal) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

How This Interaction Works

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluconazole is a azole antifungal and Naproxen is a nonsteroidal anti-inflammatory drug (nsaid); together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.

If You Take Both Medications

If you have been prescribed both Fluconazole and Naproxen, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

From the FDA Label

Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

Frequently Asked Questions

Can you take Fluconazole and Naproxen together?

Fluconazole and Naproxen have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

How serious is the Fluconazole and Naproxen interaction?

It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.

What should I do if I'm taking both Fluconazole and Naproxen?

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

Other Fluconazole Interactions

Other Naproxen Interactions

Sources & References

Learn more about where our data comes from and how we write and review medical content.