Does Diclofenac Interact With Fluconazole?

Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).

Severity: Minor

Severity basis: drug interactions section. Combining Diclofenac (Nonsteroidal anti-inflammatory drug (NSAID)) and Fluconazole (Azole antifungal) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Diclofenac

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Voltaren, Cambia

View Diclofenac safety profile

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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