Does Aspirin Interact With Diclofenac?

Warnings For external use only Allergy alert: Diclofenac may cause a severe allergic reaction, especially in people allergic to aspirin.

Severity: Minor

Severity basis: warnings section. Combining Aspirin (Antiplatelet / NSAID) and Diclofenac (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Warnings For external use only Allergy alert: Diclofenac may cause a severe allergic reaction, especially in people allergic to aspirin.

Source: FDA structured product labeling (set_id 005299ac-b6de-511f-e063-6294a90a29e0).

Aspirin

Antiplatelet / NSAID

Brands: Bayer, Ecotrin, Bufferin

View Aspirin safety profile

Diclofenac

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Voltaren, Cambia

View Diclofenac safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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