Does Aspirin Interact With Methylprednisolone?

Methylprednisolone may increase the clearance of chronic high dose aspirin.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Aspirin (Antiplatelet / NSAID) and Methylprednisolone (Systemic corticosteroid) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Methylprednisolone may increase the clearance of chronic high dose aspirin.

Source: FDA structured product labeling (set_id 01f0126c-da22-4ac0-8755-3bc589602e6a).

Aspirin

Antiplatelet / NSAID

Brands: Bayer, Ecotrin, Bufferin

View Aspirin safety profile

Methylprednisolone

Systemic corticosteroid

Brands: Medrol

View Methylprednisolone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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