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    HomeMedication GuideAspirin Safety
    Antiplatelet / NSAID

    Aspirin: What to Know Before You Take It

    Also sold as Bayer, Ecotrin, Bufferin

    What Aspirin Is Used For

    Uses for the temporary relief of minor aches and pains or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief. ask your doctor about other uses for safety coated 81 mg aspirin

    Warnings

    Warnings Reye's syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction, which may include: hives facial swelling shock asthma (wheezing) Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Do not use if you are allergic to aspirin or any other pain reliever/fever reducer. if you have ever had an allergic reaction to his product or any of its ingredients Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stool have stomach pain that does not get better pain gets worse or lasts more than 10 days redness or swelling is present ringing in the ears or loss of hearing occurs new symptoms occur These could be signs of a serious condition If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

    Aspirin Drug Interactions (38)

    Aspirin + Celecoxib
    History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
    Contraindicated interaction
    Aspirin + Indomethacin
    History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
    Contraindicated interaction
    Aspirin + Ketorolac
    Ketorolac tromethamine should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
    Contraindicated interaction
    Aspirin + Meloxicam
    4 CONTRAINDICATIONS Meloxicam is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to meloxicam or any components of the drug product [see Warnings and Precautions ( 5.7 , 5.9 ) ] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
    Contraindicated interaction
    Aspirin + Naproxen
    4 CONTRAINDICATIONS Naproxen tablets and naproxen sodium tablets are contraindicated in the following patients: • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to naproxen or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
    Contraindicated interaction
    Aspirin + Fluoxetine
    NSAIDs, Aspirin, Warfarin): May potentiate the risk of bleeding ( 7.4 ) Drugs Tightly Bound to Plasma Proteins: May cause a shift in plasma concentrations ( 7.6 , 7.7 ) Olanzapine: When used in combination with fluoxetine, also refer to the Drug Interactions section of the package insert for Symbyax ( 7.7 ) Drugs that Prolong the QT Interval: Do not use fluoxetine with thioridazine or pimozide.
    Major interaction
    Aspirin + Ibuprofen
    The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Do not use if you are allergic to aspirin or any other pain reliever/fever reducer.
    Major interaction
    Aspirin + Methotrexate
    If coadministration cannot be avoided, monitor closely for methotrexate adverse reactions when coadministered with: Oral antibiotics (including neomycin) Antifolate drugs (e.g., dapsone, pemetrexed, pyrimethamine and sulfonamides) Oral or intravenous penicillin or sulfonamide antibiotics Aspirin and other nonsteroidal anti- inflammatory drugs Hepatotoxic products Highly protein-bound drugs (e.g., oral anticoagulants, phenytoin, salicylates, sulfonamides, sulfonylureas, and tetracyclines) Prot…
    Major interaction
    Aspirin + Montelukast
    • Patients with known aspirin sensitivity should continue to avoid aspirin or non-steroidal anti-inflammatory agents while taking montelukast sodium ( 5.4 ).
    Major interaction
    Aspirin + Alendronate
    ( 7.1 ) Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation.
    Moderate interaction
    Aspirin + Citalopram
    Increased Risk of Bleeding : Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin and other anticoagulants may increase this risk ( 5.4 ) .
    Moderate interaction
    Aspirin + Desvenlafaxine
    Examples NSAIDs, aspirin, and warfarin Drugs that are Primarily Metabolized by CYP2D6 Clinical Impact Concomitant use of PRISTIQ increases C max and AUC of a drug primarily metabolized by CYP2D6 which may increase the risk of toxicity of the CYP2D6 substrate drug [see Clinical Pharmacology (12.3) ] .
    Moderate interaction
    Aspirin + Edoxaban
    Promptly evaluate any signs or symptoms of blood loss if patients are treated concomitantly with anticoagulants, aspirin, other platelet aggregation inhibitors, and/or NSAIDs [see Warnings and Precautions (5.3) ] .
    Moderate interaction
    Aspirin + Escitalopram
    If serotonin syndrome occurs, consider discontinuation of escitalopram and/or concomitant serotonergic drugs [ see Warnings and Precautions(5.2) ] Drugs That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) Clinical Impact: Concomitant use of escitalopram and an antiplatelet or anticoagulant may potentiate the risk of bleeding.
    Moderate interaction
    Aspirin + Methylprednisolone
    Methylprednisolone may increase the clearance of chronic high dose aspirin.
    Moderate interaction
    Aspirin + Paroxetine
    ( 5.4 , 8.1 ) Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk.
    Moderate interaction
    Aspirin + Rivaroxaban
    7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].
    Moderate interaction
    Aspirin + Spironolactone
    Acetylsalicylic Acid (ASA): ASA may reduce the efficacy of spironolactone ( 7.6 ) Abiraterone: May increase prostate-specific antigen (PSA) levels ( 7.7 ).
    Moderate interaction
    Aspirin + Trazodone
    NSAIDs, Aspirin, or Other Drugs Affecting Coagulation or Bleeding Due to a possible association between serotonin modulating drugs and gastrointestinal bleeding, patients should be monitored for and cautioned about the potential risk of bleeding associated with the concomitant use of trazodone and NSAIDs, aspirin, or other drugs that affect coagulation or bleeding [s ee Warnings and Precautions ( 5.7 ) ].
    Moderate interaction
    Aspirin + Valproic Acid
    Therefore increased monitoring of valproate and concomitant drug concentrations and dosage adjustment are indicated whenever enzyme- inducing or inhibiting drugs are introduced or withdrawn ( 7.1 ) Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives: Monitoring of valproate concentrations is recommended ( 7.1 ) Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g.
    Moderate interaction
    Aspirin + Apixaban
    7.3 Anticoagulants and Antiplatelet Agents Coadministration of antiplatelet agents, fibrinolytics, heparin, aspirin, and chronic NSAID use increases the risk of bleeding.
    Minor interaction
    Aspirin + Atenolol
    Information on concurrent usage of atenolol and aspirin is limited.
    Minor interaction
    Aspirin + Atomoxetine
    Atomoxetine did not affect the binding of warfarin, acetylsalicylic acid, phenytoin, or diazepam to human albumin.
    Minor interaction
    Aspirin + Dexamethasone
    Nonsteroidal Anti-Inflammatory Agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal ant i nflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects.
    Minor interaction
    Aspirin + Diclofenac
    Warnings For external use only Allergy alert: Diclofenac may cause a severe allergic reaction, especially in people allergic to aspirin.
    Minor interaction
    Aspirin + Duloxetine
    7.4 Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Serotonin release by platelets plays an important role in hemostasis.
    Minor interaction
    Aspirin + Enoxaparin
    These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone.
    Minor interaction
    Aspirin + Finasteride
    7.2 Other Concomitant Therapy Although specific interaction studies were not performed, finasteride doses of 1 mg or more were concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, analgesics, angiotensin-converting enzyme (ACE) inhibitors, anticonvulsants, benzodiazepines, beta blockers, calcium-channel blockers, cardiac nitrates, diuretics, H 2 antagonists, HMG-CoA reductase inhibitors, prostaglandin synthetase inhibitors (also referred to as NSAIDs), …
    Minor interaction
    Aspirin + Furosemide
    One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency.
    Minor interaction
    Aspirin + Levothyroxine
    5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity.
    Minor interaction
    Aspirin + Nitroglycerin
    Drug interactions Aspirin: Coadministration of nitroglycerin with high dose aspirin (1000 mg) results in increased exposure to nitroglycerin.
    Minor interaction
    Aspirin + Oseltamivir
    7.2 Drugs Without Clinically Significant Drug Interaction with Oseltamivir Phosphate for Oral Suspension No dose adjustments are needed for either oseltamivir or the concomitant drug when coadministering oseltamivir with amoxicillin, acetaminophen, aspirin, cimetidine, antacids (magnesium and aluminum hydroxides and calcium carbonates), rimantadine, amantadine, or warfarin [see Clinical Pharmacology (12.3) ] .
    Minor interaction
    Aspirin + Sertraline
    Drugs that Interfere with Hemostasis (Non-selective NSAIDs, Aspirin, Warfarin, etc.) Serotonin release by platelets plays an important role in hemostasis.
    Minor interaction
    Aspirin + Sildenafil
    In humans, sildenafil has no effect on bleeding time when taken alone or with aspirin.
    Minor interaction
    Aspirin + Tadalafil
    7.3 Potential for Tadalafil Tablets to Affect Other Drugs Aspirin — Tadalafil did not potentiate the increase in bleeding time caused by aspirin.
    Minor interaction
    Aspirin + Venlafaxine
    Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Serotonin release by platelets plays an important role in hemostasis.
    Minor interaction
    Aspirin + Verapamil
    Aspirin: In a few reported cases, co-administration of verapamil with aspirin has led to increased bleeding times greater than observed with aspirin alone.
    Minor interaction
    Aspirin + Warfarin
    Table 3: Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Non-steroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafax…
    Minor interaction

    Check Aspirin against your full medication list in our free Interaction Checker

    Most-Reported Side Effects

    Based on 552,493 reports in the FDA Adverse Event Reporting System (FAERS). Reports do not prove the drug caused the effect.

    fatigue33,496nausea28,426dyspnoea28,269diarrhoea27,590drug ineffective26,526dizziness23,608headache21,366off label use19,976asthenia19,581fall19,367pain19,172vomiting16,808

    Explore full Aspirin safety data in our free FDA Safety Explorer

    FDA Recalls (5)

    Class IIOngoingOct 17, 2025

    Labeling: Label Mix-up. This issue affects the outer box labeling only. The box incorrectly states the ingredients Acetaminophen 500mg and Caffeine 65mg. The inner pouch correctly states the ingredients are Aspirin (NSAID)*500mg and Caffeine 32.5mg.

    Recalling firm: Aero Healthcare

    Class IIOngoingNov 11, 2024

    cGMP Deviations: Observations were made that some blister card-foils were separating from the blister cavity.

    Recalling firm: Safecor Health, LLC

    Class IOngoingJul 11, 2024

    Labeling: Missing Label - some bottles are missing the the manufacturers label that includes the drug facts information.

    Recalling firm: Aurobindo Pharma USA Inc

    Class IIIOngoingJun 29, 2022

    Failed Tablet/Capsule Specification : Capsule breakage

    Recalling firm: Glenmark Pharmaceuticals Inc., USA

    Class IITerminatedJan 26, 2022

    CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.

    Recalling firm: CARDINAL HEALTHCARE

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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