Does Cyclosporine Interact With Rosuvastatin?
Steps to Prevent or Reduce the Risk of Myopathy and Rhabdomyolysis The concomitant use of rosuvastatin with cyclosporine or gemfibrozil is not recommended.
Severity: Major
Severity basis: warnings section (keywords: not recommended). Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Rosuvastatin (HMG-CoA reductase inhibitor (statin)) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Cyclosporine is a calcineurin inhibitor immunosuppressant and Rosuvastatin is a hmg-coa reductase inhibitor (statin); together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Cyclosporine and Rosuvastatin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Steps to Prevent or Reduce the Risk of Myopathy and Rhabdomyolysis The concomitant use of rosuvastatin with cyclosporine or gemfibrozil is not recommended.
Source: FDA structured product labeling (set_id 02797697-300a-43db-92cf-9b78f08626be).
Cyclosporine
Calcineurin inhibitor immunosuppressant
Brands: Neoral, Sandimmune, Gengraf
View Cyclosporine safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Cyclosporine and Rosuvastatin together?
Cyclosporine and Rosuvastatin have a documented major interaction. The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How serious is the Cyclosporine and Rosuvastatin interaction?
It is classified as a major interaction, based on the FDA label's warnings section (keywords: not recommended). A major interaction can cause serious harm and often calls for a change in therapy or close monitoring.
What should I do if I'm taking both Cyclosporine and Rosuvastatin?
If you have been prescribed both Cyclosporine and Rosuvastatin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Cyclosporine Interactions
- Cyclosporine + Simvastatin(contraindicated)
- Cyclosporine + Atorvastatin(major)
- Cyclosporine + Clarithromycin(major)
- Cyclosporine + Lovastatin(major)
- Cyclosporine + Adalimumab(moderate)
- Cyclosporine + Allopurinol(moderate)
- Cyclosporine + Amlodipine(moderate)
- Cyclosporine + Carbamazepine(moderate)
- Cyclosporine + Carvedilol(moderate)
- Cyclosporine + Celecoxib(moderate)
- Cyclosporine + Colchicine(moderate)
- Cyclosporine + Fluconazole(moderate)
- Cyclosporine + Furosemide(moderate)
- Cyclosporine + Indomethacin(moderate)
- Cyclosporine + Itraconazole(moderate)
- Cyclosporine + Meloxicam(moderate)
- Cyclosporine + Naproxen(moderate)
- Cyclosporine + Phenytoin(moderate)
- Cyclosporine + Pravastatin(moderate)
- Cyclosporine + Rifampin(moderate)
- Cyclosporine + Verapamil(moderate)
- Cyclosporine + Amiodarone(minor)
- Cyclosporine + Ciprofloxacin(minor)
- Cyclosporine + Dexamethasone(minor)
- Cyclosporine + Digoxin(minor)
- Cyclosporine + Diltiazem(minor)
- Cyclosporine + Ezetimibe(minor)
- Cyclosporine + Fenofibrate(minor)
- Cyclosporine + Hydroxychloroquine(minor)
- Cyclosporine + Levofloxacin(minor)
- Cyclosporine + Methotrexate(minor)
- Cyclosporine + Metoclopramide(minor)
- Cyclosporine + Modafinil(minor)
- Cyclosporine + Tacrolimus(minor)
- Cyclosporine + Warfarin(minor)