Does Cyclosporine Interact With Fluconazole?

(See PRECAUTIONS .) Cyclosporine: Cyclosporine AUC and C max were determined before and after the administration of fluconazole 200 mg daily for 14 days in eight renal transplant patients who had been on cyclosporine therapy for at least 6 months and on a stable cyclosporine dose for at least 6 weeks.

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Fluconazole (Azole antifungal) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

(See PRECAUTIONS .) Cyclosporine: Cyclosporine AUC and C max were determined before and after the administration of fluconazole 200 mg daily for 14 days in eight renal transplant patients who had been on cyclosporine therapy for at least 6 months and on a stable cyclosporine dose for at least 6 weeks.

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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