Does Cyclosporine Interact With Fluconazole?
(See PRECAUTIONS .) Cyclosporine: Cyclosporine AUC and C max were determined before and after the administration of fluconazole 200 mg daily for 14 days in eight renal transplant patients who had been on cyclosporine therapy for at least 6 months and on a stable cyclosporine dose for at least 6 weeks.
Severity: Moderate
Severity basis: drug interactions section (keywords: caution). Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Fluconazole (Azole antifungal) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Cyclosporine is a calcineurin inhibitor immunosuppressant and Fluconazole is a azole antifungal; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Cyclosporine and Fluconazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
(See PRECAUTIONS .) Cyclosporine: Cyclosporine AUC and C max were determined before and after the administration of fluconazole 200 mg daily for 14 days in eight renal transplant patients who had been on cyclosporine therapy for at least 6 months and on a stable cyclosporine dose for at least 6 weeks.
Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).
Cyclosporine
Calcineurin inhibitor immunosuppressant
Brands: Neoral, Sandimmune, Gengraf
View Cyclosporine safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Cyclosporine and Fluconazole together?
Cyclosporine and Fluconazole have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Cyclosporine and Fluconazole interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Cyclosporine and Fluconazole?
If you have been prescribed both Cyclosporine and Fluconazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Cyclosporine Interactions
- Cyclosporine + Simvastatin(contraindicated)
- Cyclosporine + Atorvastatin(major)
- Cyclosporine + Clarithromycin(major)
- Cyclosporine + Lovastatin(major)
- Cyclosporine + Rosuvastatin(major)
- Cyclosporine + Adalimumab(moderate)
- Cyclosporine + Allopurinol(moderate)
- Cyclosporine + Amlodipine(moderate)
- Cyclosporine + Carbamazepine(moderate)
- Cyclosporine + Carvedilol(moderate)
- Cyclosporine + Celecoxib(moderate)
- Cyclosporine + Colchicine(moderate)
- Cyclosporine + Furosemide(moderate)
- Cyclosporine + Indomethacin(moderate)
- Cyclosporine + Itraconazole(moderate)
- Cyclosporine + Meloxicam(moderate)
- Cyclosporine + Naproxen(moderate)
- Cyclosporine + Phenytoin(moderate)
- Cyclosporine + Pravastatin(moderate)
- Cyclosporine + Rifampin(moderate)
- Cyclosporine + Verapamil(moderate)
- Cyclosporine + Amiodarone(minor)
- Cyclosporine + Ciprofloxacin(minor)
- Cyclosporine + Dexamethasone(minor)
- Cyclosporine + Digoxin(minor)
- Cyclosporine + Diltiazem(minor)
- Cyclosporine + Ezetimibe(minor)
- Cyclosporine + Fenofibrate(minor)
- Cyclosporine + Hydroxychloroquine(minor)
- Cyclosporine + Levofloxacin(minor)
- Cyclosporine + Methotrexate(minor)
- Cyclosporine + Metoclopramide(minor)
- Cyclosporine + Modafinil(minor)
- Cyclosporine + Tacrolimus(minor)
- Cyclosporine + Warfarin(minor)
Other Fluconazole Interactions
- Fluconazole + Clarithromycin(major)
- Fluconazole + Rifampin(major)
- Fluconazole + Amiodarone(moderate)
- Fluconazole + Glimepiride(moderate)
- Fluconazole + Glipizide(moderate)
- Fluconazole + Glyburide(moderate)
- Fluconazole + Phenytoin(moderate)
- Fluconazole + Tacrolimus(moderate)
- Fluconazole + Warfarin(moderate)
- Fluconazole + Amitriptyline(minor)
- Fluconazole + Amlodipine(minor)
- Fluconazole + Atorvastatin(minor)
- Fluconazole + Azithromycin(minor)
- Fluconazole + Carbamazepine(minor)
- Fluconazole + Carvedilol(minor)
- Fluconazole + Celecoxib(minor)
- Fluconazole + Clonazepam(minor)
- Fluconazole + Diclofenac(minor)
- Fluconazole + Estradiol(minor)
- Fluconazole + Hydrochlorothiazide(minor)
- Fluconazole + Ibuprofen(minor)
- Fluconazole + Losartan(minor)
- Fluconazole + Meloxicam(minor)
- Fluconazole + Naproxen(minor)
- Fluconazole + Nifedipine(minor)
- Fluconazole + Nortriptyline(minor)
- Fluconazole + Prednisone(minor)
- Fluconazole + Simvastatin(minor)
- Fluconazole + Verapamil(minor)