Does Cyclosporine Interact With Modafinil?

7 DRUG INTERACTIONS Effects of Modafinil on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 (e.g., steroidal contraceptives, cyclosporine, midazolam, and triazolam) may be increased by modafinil via induction of metabolic enzymes, which results in lower systemic exposure.

Severity: Minor

Severity basis: drug interactions section. Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Modafinil (Wakefulness-promoting agent) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

7 DRUG INTERACTIONS Effects of Modafinil on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 (e.g., steroidal contraceptives, cyclosporine, midazolam, and triazolam) may be increased by modafinil via induction of metabolic enzymes, which results in lower systemic exposure.

Source: FDA structured product labeling (set_id 013450dd-cd42-46c7-98d6-9a2925761978).

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Modafinil

Wakefulness-promoting agent

Brands: Provigil

View Modafinil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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