Does Fluconazole Interact With Glyburide?
(See CONTRAINDICATIONS and PRECAUTIONS .) Oral hypoglycemics: The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers.
Severity: Moderate
Severity basis: drug interactions section (keywords: caution). Combining Fluconazole (Azole antifungal) and Glyburide (Sulfonylurea) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluconazole is a azole antifungal and Glyburide is a sulfonylurea; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Fluconazole and Glyburide, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
(See CONTRAINDICATIONS and PRECAUTIONS .) Oral hypoglycemics: The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers.
Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Fluconazole and Glyburide together?
Fluconazole and Glyburide have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Fluconazole and Glyburide interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Fluconazole and Glyburide?
If you have been prescribed both Fluconazole and Glyburide, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Fluconazole Interactions
- Fluconazole + Clarithromycin(major)
- Fluconazole + Rifampin(major)
- Fluconazole + Amiodarone(moderate)
- Fluconazole + Cyclosporine(moderate)
- Fluconazole + Glimepiride(moderate)
- Fluconazole + Glipizide(moderate)
- Fluconazole + Phenytoin(moderate)
- Fluconazole + Tacrolimus(moderate)
- Fluconazole + Warfarin(moderate)
- Fluconazole + Amitriptyline(minor)
- Fluconazole + Amlodipine(minor)
- Fluconazole + Atorvastatin(minor)
- Fluconazole + Azithromycin(minor)
- Fluconazole + Carbamazepine(minor)
- Fluconazole + Carvedilol(minor)
- Fluconazole + Celecoxib(minor)
- Fluconazole + Clonazepam(minor)
- Fluconazole + Diclofenac(minor)
- Fluconazole + Estradiol(minor)
- Fluconazole + Hydrochlorothiazide(minor)
- Fluconazole + Ibuprofen(minor)
- Fluconazole + Losartan(minor)
- Fluconazole + Meloxicam(minor)
- Fluconazole + Naproxen(minor)
- Fluconazole + Nifedipine(minor)
- Fluconazole + Nortriptyline(minor)
- Fluconazole + Prednisone(minor)
- Fluconazole + Simvastatin(minor)
- Fluconazole + Verapamil(minor)