Does Azithromycin Interact With Fluconazole?
) Azithromycin: An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 800 mg oral dose of fluconazole on the pharmacokinetics of a single 1200 mg oral dose of azithromycin as well as the effects of azithromycin on the pharmacokinetics of fluconazole.
Severity: Minor
Severity basis: drug interactions section. Combining Azithromycin (Macrolide antibiotic) and Fluconazole (Azole antifungal) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
) Azithromycin: An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 800 mg oral dose of fluconazole on the pharmacokinetics of a single 1200 mg oral dose of azithromycin as well as the effects of azithromycin on the pharmacokinetics of fluconazole.
Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Azithromycin Interactions
Other Fluconazole Interactions
- Fluconazole + Clarithromycin(major)
- Fluconazole + Rifampin(major)
- Fluconazole + Amiodarone(moderate)
- Fluconazole + Cyclosporine(moderate)
- Fluconazole + Glimepiride(moderate)
- Fluconazole + Glipizide(moderate)
- Fluconazole + Glyburide(moderate)
- Fluconazole + Phenytoin(moderate)
- Fluconazole + Tacrolimus(moderate)
- Fluconazole + Warfarin(moderate)
- Fluconazole + Amitriptyline(minor)
- Fluconazole + Amlodipine(minor)
- Fluconazole + Atorvastatin(minor)
- Fluconazole + Carbamazepine(minor)
- Fluconazole + Carvedilol(minor)
- Fluconazole + Celecoxib(minor)
- Fluconazole + Clonazepam(minor)
- Fluconazole + Diclofenac(minor)
- Fluconazole + Estradiol(minor)
- Fluconazole + Hydrochlorothiazide(minor)
- Fluconazole + Ibuprofen(minor)
- Fluconazole + Losartan(minor)
- Fluconazole + Meloxicam(minor)
- Fluconazole + Naproxen(minor)
- Fluconazole + Nifedipine(minor)
- Fluconazole + Nortriptyline(minor)
- Fluconazole + Prednisone(minor)
- Fluconazole + Simvastatin(minor)
- Fluconazole + Verapamil(minor)