Does Fluconazole Interact With Warfarin?

(See PRECAUTIONS .) Warfarin: There was a significant increase in prothrombin time response (area under the prothrombin time-time curve) following a single dose of warfarin (15 mg) administered to 13 normal male volunteers following oral fluconazole 200 mg administered daily for 14 days as compared to the administration of warfarin alone.

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Fluconazole (Azole antifungal) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

(See PRECAUTIONS .) Warfarin: There was a significant increase in prothrombin time response (area under the prothrombin time-time curve) following a single dose of warfarin (15 mg) administered to 13 normal male volunteers following oral fluconazole 200 mg administered daily for 14 days as compared to the administration of warfarin alone.

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Warfarin

Vitamin K antagonist anticoagulant

Brands: Coumadin, Jantoven

View Warfarin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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