Does Azithromycin Interact With Warfarin?

() • Warfarin: Use with azithromycin may increase coagulation times; monitor prothrombin time.

Severity: Moderate

Severity basis: drug interactions section (keywords: monitor, may increase). Combining Azithromycin (Macrolide antibiotic) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

() • Warfarin: Use with azithromycin may increase coagulation times; monitor prothrombin time.

Source: FDA structured product labeling (set_id 003307c5-3f73-4a5d-a704-bfdea3c656e8).

Azithromycin

Macrolide antibiotic

Brands: Zithromax, Z-Pak

View Azithromycin safety profile

Warfarin

Vitamin K antagonist anticoagulant

Brands: Coumadin, Jantoven

View Warfarin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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