Does Hydrochlorothiazide Interact With Lithium?

Lithium generally should not be given with diuretics (see PRECAUTIONS , Drug Interactions ).

Severity: Moderate

Severity basis: warnings section (keywords: caution). Combining Hydrochlorothiazide (Thiazide diuretic) and Lithium (Mood stabilizer) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Lithium generally should not be given with diuretics (see PRECAUTIONS , Drug Interactions ).

Source: FDA structured product labeling (set_id 01ad3531-5ed9-434c-b7d5-02d72aa82e46).

Hydrochlorothiazide

Thiazide diuretic

Brands: Microzide, HydroDiuril

View Hydrochlorothiazide safety profile

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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