Does Lithium Interact With Metronidazole?

7 DRUG INTERACTIONS • Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Lithium (Mood stabilizer) and Metronidazole (Nitroimidazole antibiotic) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

7 DRUG INTERACTIONS • Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.

Source: FDA structured product labeling (set_id 01c4facd-ed79-4078-ba33-2044de372d0f).

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Metronidazole

Nitroimidazole antibiotic

Brands: Flagyl

View Metronidazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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