Does Modafinil Interact With Warfarin?

Warfarin More frequent monitoring of prothrombin times/INR should be considered whenever modafinil is coadministered with warfarin [see Clinical Pharmacology ( 12.3 )] .

Severity: Moderate

Severity basis: drug interactions section (keywords: monitor, consider). Combining Modafinil (Wakefulness-promoting agent) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Warfarin More frequent monitoring of prothrombin times/INR should be considered whenever modafinil is coadministered with warfarin [see Clinical Pharmacology ( 12.3 )] .

Source: FDA structured product labeling (set_id 013450dd-cd42-46c7-98d6-9a2925761978).

Modafinil

Wakefulness-promoting agent

Brands: Provigil

View Modafinil safety profile

Warfarin

Vitamin K antagonist anticoagulant

Brands: Coumadin, Jantoven

View Warfarin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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