Does Edoxaban Interact With Warfarin?

Name: Does Edoxaban Interact With Warfarin?
Creator: OmniRx Health

In the ENGAGE AF-TIMI 48 study, nonvalvular atrial fibrillation patients with CrCL > 95 mL/min had an increased rate of ischemic stroke with SAVAYSA 60 mg once daily compared to patients treated with warfarin.

Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

Severity: Moderate

Severity basis: boxed warning (keywords: boxed warning). Combining Edoxaban (Factor Xa inhibitor anticoagulant) and Warfarin (Vitamin K antagonist anticoagulant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How This Interaction Works

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Edoxaban is a factor xa inhibitor anticoagulant and Warfarin is a vitamin k antagonist anticoagulant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

If You Take Both Medications

If you have been prescribed both Edoxaban and Warfarin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

From the FDA Label

In the ENGAGE AF-TIMI 48 study, nonvalvular atrial fibrillation patients with CrCL > 95 mL/min had an increased rate of ischemic stroke with SAVAYSA 60 mg once daily compared to patients treated with warfarin.

Source: FDA structured product labeling (set_id e77d3400-56ad-11e3-949a-0800200c9a66).

Edoxaban

Factor Xa inhibitor anticoagulant

Brands: Savaysa

View Edoxaban safety profile

Warfarin

Vitamin K antagonist anticoagulant

Brands: Coumadin, Jantoven

View Warfarin safety profile

Check these against your full medication list in our free Interaction Checker

Frequently Asked Questions

Can you take Edoxaban and Warfarin together?

Edoxaban and Warfarin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How serious is the Edoxaban and Warfarin interaction?

It is classified as a moderate interaction, based on the FDA label's boxed warning (keywords: boxed warning). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

What should I do if I'm taking both Edoxaban and Warfarin?

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

Other Edoxaban Interactions

Other Warfarin Interactions

Sources & References

Learn more about where our data comes from and how we write and review medical content.