Does Tamsulosin Interact With Warfarin?

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Tamsulosin is a alpha-1 blocker (bph) and Warfarin is a vitamin k antagonist anticoagulant; together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Tamsulosin and Warfarin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

(5.2, 7.1, 12.3) Should not be used in combination with other alpha adrenergic blocking agents (5.2, 7.2, 12.3) Exercise caution with concomitant administration of warfarin (5.2, 7.4, 12.3) Advise patients about the possibility and seriousness of priapism (5.3) Intraoperative Floppy Iris Syndrome has been observed during cataract and glaucoma surgery in some patients.

Source: FDA structured product labeling (set_id 00097e78-9c04-4e62-8260-ddb50e9a6a93).